Engineering Multifunctional Nanoparticles for AML

PI’s: YongTae Kim, Wilbur Lam, & Jessica Lin

Current induction chemotherapies for treating AML involve severe adverse effects, particularly causing cardiac complications. Advanced treatment of cancer needs controlled targeted delivery of therapeutic and diagnostic nanomaterials. Despite several nanomedicines that have been developed for cancer, targeted drug delivery to tumor cells in blood circulation, including leukemic cells, remains challenging due to the lack of nanomedical transporters that can combine high drug loading efficiency, high targeting efficacy, and robust stability of natural nanomaterials.

In the current proposal, we propose to develop a new therapeutic nanoparticle platform that allows targeted delivery of a cytostatic drug to cancer cells and to evaluate the efficacy in a microfluidic device.

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